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Article

Genetic and biochemical characterization of human AP endonuclease 1 mutants deficient in nucleotide incision repair activity.

PloS one - 17 Aug 2010

Gelin Aurore, Redrejo-Rodríguez Modesto, Laval Jacques, Fedorova Olga S, Saparbaev Murat, Ishchenko Alexander A

Abstract excerpt

BACKGROUND: Human apurinic/apyrimidinic endonuclease 1 (APE1) is a key DNA repair enzyme involved in both base excision repair (BER) and nucleotide incision repair (NIR) pathways. In the BER pathway, APE1 cleaves DNA at AP sites and 3'-blocking moieties generated by DNA glycosylases. In the NIR pathway, APE1 incises DNA 5' to a number of oxidatively damaged bases. At present, physiological relevance of the NIR...

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Identifiers

PMID: 20808930
DOI: 10.1371/journal.pone.0012241
PMCID: PMC2923195

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