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Article

APE1 senses DNA single-strand breaks for repair and signaling

5 Dec 2019

Abstract excerpt

DNA single-strand breaks (SSBs) represent the most abundant type of DNA damage. Unrepaired SSBs impair DNA replication and transcription, leading to cancer and neurodegenerative disorders. Although PARP1 and XRCC1 are implicated in the SSB repair pathway, it remains unclear how SSB repair and SSB signaling pathways are coordinated and regulated. Using Xenopus egg extract and in vitro reconstitution systems, here...

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PMID: 31828326
DOI: 10.1093/nar/gkz1175

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