Article

LicochalconeB Inhibits cGAS-STING Signaling Pathway and Prevents Autoimmunity Diseases

2023-08-02

Abstract excerpt

Cytosolic DNA activates the STING (stimulator of interferon genes) signaling pathway to trigger interferon and inflammatory responses that protect against microbial infections and cancer. However, Aicardi–Goutières syndrome (AGS) persistently activates the STING signaling pathway, which can lead to severe autoimmune diseases. We demonstrate herein that Licochalcone B (LicoB), the main component of traditional lico...

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Literature Corpus work: c2c2f335-a715-5dea-97e1-faaaf0019482
DOI: 10.21203/rs.3.rs-3210272/v1

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