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Article

Neuroprotective effects of granulocyte-colony stimulating factor in a novel transgenic mouse model of SCA17.

Journal of neurochemistry - 1 Jul 2011

Chang Ya-Chin, Lin Cheng-Yueh, Hsu Chen-Ming, Lin Hsin-Chieh, Chen Yu-Hsiang, Lee-Chen Guey-Jen, Su Ming-Tsan, Ro Long-Sun, Chen Chiung-Mei, Hsieh-Li Hsiu Mei

Abstract excerpt

Spinocerebellar ataxia type 17 (SCA17) is an autosomal dominant inherited disorder characterized by degeneration of spinocerebellar tracts and selected brainstem neurons owing to the expansion of a CAG repeat of the human TATA-binding protein (hTBP) gene. To gain insight into the pathogenesis of this hTBP mutation, we generated transgenic mice with the mutant hTBP gene driven by the Purkinje specific protein...

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PMID: 21554323
DOI: 10.1111/j.1471-4159.2011.07304.x

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