Article

Cerebellar developmental deficits underlie neurodegenerative disorder spinocerebellar ataxia type 23

2020-05-10

Abstract excerpt

<title>Abstract</title> <p>Background Spinocerebellar ataxia type 23 (SCA23) is a late-onset neurodegenerative disorder characterized by slowly progressive gait and limb ataxia, for which there is no therapy available. It is caused by mutations in <italic>PDYN</italic>, which encodes the opioid precursor protein prodynorphin (PDYN). PDYN is processed into the opioid peptides α-neoendorphin, and dynorphins (Dyn)...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bc14113f-6caf-5cac-890e-8b41fbe05889
DOI: 10.21203/rs.3.rs-26966/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cerebellar developmental deficits underlie neurodegenerative disorder spinocerebellar ataxia type 23DOI 10.21203/rs.3.rs-26966/v1Read

Elevated mutant dynorphin A causes Purkinje cell loss and motor dysfunction in spinocerebellar ataxia type 23.Semantic proximity Read

Spinocerebellar Ataxia Type 23 (SCA23): a rare cause of SCA in the AmericasSemantic proximity Read

A Novel Early Onset Spinocerebellar Ataxia 13 BAC Mouse Model with Cerebellar Hypoplasia, Tremor, and Ataxic GaitSemantic proximity Read

Cerebellar ataxias: β-III spectrin's interactions suggest common pathogenic pathways.Semantic proximity Read

Association of cerebellar inflammation and neurodegeneration in a novel spinocerebellar ataxia type 13 mouse modelSemantic proximity Read

Cerebellar ataxias: an update.Semantic proximity Read

Purkinje Cell Patterning-Insights from Single-Cell Sequencing.Semantic proximity Read

Behavioral regression in shank3Δex4-22 mice during early adulthood corresponds to cerebellar granule cell glutamatergic synaptic changesSemantic proximity Read

The autosomal dominant spinocerebellar ataxias: emerging mechanistic themes suggest pervasive Purkinje cell vulnerabilitySemantic proximity Read

Developmental roots of cerebellar degeneration in spinocerebellar ataxia.Semantic proximity Read

Identification and characterization of novel PDYN mutations in dominant cerebellar ataxia cases.Semantic proximity Read

A Novel SCA3 Knock-in Mouse Model Mimics the Human SCA3 Disease Phenotype Including Neuropathological, Behavioral, and Transcriptional Abnormalities Especially in OligodendrocytesSemantic proximity Read