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Article

ERK activation precedes Purkinje cell loss in mice with Spinocerebellar ataxia type 17.

Neuroscience letters - 1 Nov 2020

Lin Chia-Wei, Fan Chia-Hao, Chang Ya-Chin, Hsieh-Li Hsiu Mei

Abstract excerpt

Spinocerebellar ataxia type 17 (SCA17) is an autosomal dominant neurodegenerative disease caused by CAG expansion in the gene encoding the TATA-binding protein (TBP). The neurological features of SCA17 are Purkinje cell loss and gliosis. We have generated SCA17 transgenic mice which recapitulate the patients' phenotypes and are suitable for the study of the SCA17 pathomechanism. Our previous study identified the...

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Identifiers

PMID: 32877710
DOI: 10.1016/j.neulet.2020.135337

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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