Article

Pathogenic tau accelerates aging-associated activation of transposable elements in the mouse central nervous system

2021-02-26

Abstract excerpt

<h4>ABSTRACT</h4> Transposable elements comprise almost half of the mammalian genome. A growing body of evidence suggests that transposable element dysregulation accompanies brain aging and neurodegenerative disorders, and that transposable element activation is neurotoxic. Recent studies have identified links between pathogenic forms of tau, a protein that accumulates in Alzheimer disease and related tauopathies...

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Literature Corpus work: 365137d9-80e8-5a89-a9c5-77d65fca3a61
DOI: 10.1101/2021.02.25.432716

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