Article

Tau isoform imbalance and aggregation are pathological hallmarks of X-linked dystonia-parkinsonism

2026-07-27

Abstract excerpt

<h4>SUMMARY</h4> Tauopathies encompass diverse neurodegenerative diseases unified by aberrant patterns of tau deposition in brain. Although most appear sporadic, some are linked to genetic etiologies that offer unique mechanistic insights. Here we report that X-linked Dystonia-Parkinsonism (XDP), caused by a non-coding retrotransposon-associated repeat insertion in TAF1 , involves a significant imbalance of tau...

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Literature Corpus work: 3b3466ae-409d-58c0-ab37-083d6af89c17
DOI: 10.64898/2026.07.23.26358614

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