Article

Specific ZNF274 binding interference at <i>SNORD116</i> activates the maternal transcripts in Prader-Willi syndrome neurons

2020-06-14

Abstract excerpt

Prader-Willi syndrome (PWS) is characterized by neonatal hypotonia, developmental delay, and hyperphagia/obesity. This disorder is caused by the absence of paternally-expressed gene products from chromosome 15q11-q13. We previously demonstrated that knocking out ZNF274, a KRAB-domain zinc finger protein capable of recruiting epigenetic machinery to deposit the H3K9me3 repressive histone modification, can activate...

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Literature Corpus work: d41c33e5-3fcd-5a9c-835a-8a1f5d18a11f
DOI: 10.1101/2020.06.13.149864

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