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Article

Zinc finger protein 274 regulates imprinted expression of transcripts in Prader-Willi syndrome neurons.

Human molecular genetics - 1 Feb 2018

Langouët Maéva, Glatt-Deeley Heather R, Chung Michael S, Dupont-Thibert Clémence M, Mathieux Elodie, Banda Erin C, Stoddard Christopher E, Crandall Leann, Lalande Marc

Abstract excerpt

Prader-Willi syndrome (PWS) is characterized by neonatal hypotonia, developmental delay and hyperphagia/obesity and is caused by the absence of paternal contribution to chromosome 15q11-q13. Using induced pluripotent stem cell (iPSC) models of PWS, we previously discovered an epigenetic complex that is comprised of the zinc-finger protein ZNF274 and the SET domain bifurcated 1 (SETDB1) histone H3 lysine 9 (H3K9)...

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Share to Chromatin Immunoprecipitation
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Genomic Imprinting

Share to Histone-Lysine N-Methyltransferase

Share to Induced Pluripotent Stem Cells

Share to Kruppel-Like Transcription Factors

Share to Prader-Willi Syndrome

Source

Identifiers

PMID: 29228278
DOI: 10.1093/hmg/ddx420

Genes

SET
SETDB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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