Article

Activation of the imprinted Prader-Willi Syndrome locus by CRISPR-based epigenome editing

2024-03-04

Abstract excerpt

<h4> <h4>Summary: </h4> </h4> Epigenome editing with DNA-targeting technologies such as CRISPR-dCas9 can be used to dissect gene regulatory mechanisms and potentially treat associated disorders. For example, Prader-Willi Syndrome (PWS) is caused by loss of paternally expressed imprinted genes on chromosome 15q11.2-q13.3, although the maternal allele is intact but epigenetically silenced. Using CRISPR repression...

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Literature Corpus work: 1ef92dcf-2559-5481-bd24-3da9129f6737
DOI: 10.1101/2024.03.03.583177

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