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Article

Maternal transcription of non-protein coding RNAs from the PWS-critical region rescues growth retardation in mice.

Scientific reports - 5 Feb 2016

Rozhdestvensky Timofey S, Robeck Thomas, Galiveti Chenna R, Raabe Carsten A, Seeger Birte, Wolters Anna, Gubar Leonid V, Brosius Jürgen, Skryabin Boris V

Abstract excerpt

Prader-Willi syndrome (PWS) is a neurogenetic disorder caused by loss of paternally expressed genes on chromosome 15q11-q13. The PWS-critical region (PWScr) contains an array of non-protein coding IPW-A exons hosting intronic SNORD116 snoRNA genes. Deletion of PWScr is associated with PWS in humans and growth retardation in mice exhibiting ~15% postnatal lethality in C57BL/6 background. Here we analysed a...

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PMID: 26848093
DOI: 10.1038/srep20398
PMCID: PMC4742849

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Source receipt: pubmed, retrieved 7 Sept 2026.

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