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Article

Reactivation of maternal SNORD116 cluster via SETDB1 knockdown in Prader-Willi syndrome iPSCs.

Human molecular genetics - 1 Sept 2014

Cruvinel Estela, Budinetz Tara, Germain Noelle, Chamberlain Stormy, Lalande Marc, Martins-Taylor Kristen

Abstract excerpt

Prader-Willi syndrome (PWS), a disorder of genomic imprinting, is characterized by neonatal hypotonia, hypogonadism, small hands and feet, hyperphagia and obesity in adulthood. PWS results from the loss of paternal copies of the cluster of SNORD116 C/D box snoRNAs and their host transcript, 116HG, on human chromosome 15q11-q13. We have investigated the mechanism of repression of the maternal SNORD116 cluster and...

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Source

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Identifiers

PMID: 24760766
DOI: 10.1093/hmg/ddu187
PMCID: PMC4481691

Genes

SETDB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Reactivation of maternal SNORD116 cluster via SETDB1 knockdown in Prader-Willi syndrome iPSCs.PMID 24760766Read ↗

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