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Article

Prader-Willi locus Snord116 RNA processing requires an active endogenous allele and neuron-specific splicing by Rbfox3/NeuN.

Human molecular genetics - 1 Dec 2018

Coulson Rochelle L, Powell Weston T, Yasui Dag H, Dileep Gayathri, Resnick James, LaSalle Janine M

Abstract excerpt

Prader-Willi syndrome (PWS), an imprinted neurodevelopmental disorder characterized by metabolic, sleep and neuropsychiatric features, is caused by the loss of paternal SNORD116, containing only non-coding RNAs (ncRNAs). The primary SNORD116 transcript is processed into small nucleolar RNAs (snoRNAs), which localize to nucleoli, and their spliced host gene 116HG, which is retained at its site of transcription....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30124848
DOI: 10.1093/hmg/ddy296
PMCID: PMC6240740

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