Article

Small molecule inhibitors of G9a reactivate the maternal PWS genes in Prader-Willi-Syndrome patient derived neural stem cells and differentiated neurons

2019-05-17

Abstract excerpt

<h4>Abstract/Summary</h4> Patients with Prader-Willi-Syndrome (PWS) display intellectual impairment, hyperphagia, and various behavioral problems during childhood that converge on a neurologic deficit. The majority of PWS patients have genetic deletions of the paternal 15q11–q13 chromosomal region, with their maternal PWS locus intact but epigenetically silenced by hypermethylation and repressive histone modulati...

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Literature Corpus work: db28dba1-3e78-5f24-aa7d-063bbbd4ba95
DOI: 10.1101/640938

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