Back to search

Article

Identifying key underlying regulatory networks and predicting targets of orphan C/D box <i>SNORD116</i> snoRNAs in Prader-Willi syndrome

2023-10-05

Abstract excerpt

Prader-Willi syndrome (PWS) is a rare neurodevelopmental disorder characterized principally by initial symptoms of neonatal hypotonia and failure-to-thrive in infancy, followed by hyperphagia and obesity. It is well established that PWS is caused by loss of paternal expression of the imprinted region on chromosome 15q11-q13. While most PWS cases exhibit megabase-scale deletions of the paternal chromosome 15q11-q13...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b98ff99a-6ee2-5367-bb4e-3da05229229a
DOI
10.1101/2023.10.03.560773
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Identifying key underlying regulatory networks and predicting targets of orphan C/D box <i>SNORD116</i> snoRNAs in Prader-Willi syndromeDOI 10.1101/2023.10.03.560773
Roles of SNORD115 and SNORD116 ncRNA clusters in neuronal differentiationSemantic proximity
Prader-Willi locus <i>Snord116</i> RNA processing requires an active endogenous allele and neuron-specific splicing by <i>Rbfox3/NeuN</i>Semantic proximity
Paternally inherited microdeletion at 15q11.2 confirms a significant role for the SNORD116 C/D box snoRNA cluster in Prader-Willi syndrome.Semantic proximity
Loss of the imprinted, non-coding Snord116 gene cluster in the interval deleted in the Prader Willi syndrome results in murine neuronal and endocrine pancreatic developmental phenotypes.Semantic proximity
Prader-Willi locus Snord116 RNA processing requires an active endogenous allele and neuron-specific splicing by Rbfox3/NeuN.Semantic proximity
Evolutionary and biological insights into the paternally expressed Snord116-Ipw-Snord115 gene array at the imprinted Prader-Willi syndrome domainSemantic proximity
Specific ZNF274 binding interference at <i>SNORD116</i> activates the maternal transcripts in Prader-Willi syndrome neuronsSemantic proximity
Non-coding RNAs Associated with Prader-Willi Syndrome Regulate Transcription of Neurodevelopmental Genes in Human Induced Pluripotent Stem CellsSemantic proximity
Reactivation of maternal SNORD116 cluster via SETDB1 knockdown in Prader-Willi syndrome iPSCs.Semantic proximity
Analysis of SNHG14: A Long Non-Coding RNA Hosting SNORD116, Whose Loss Contributes to Prader-Willi Syndrome Etiology.Semantic proximity
Maternal transcription of non-protein coding RNAs from the PWS-critical region rescues growth retardation in mice.Semantic proximity
Prader-Willi syndrome transcripts are expressed in phenotypically significant regions of the developing mouse brain.Semantic proximity
Select a neighboring publication to make it the new centre.