Article

Prader-Willi locus <i>Snord116</i> RNA processing requires an active endogenous allele and neuron-specific splicing by <i>Rbfox3/NeuN</i>

2018-04-20

Abstract excerpt

Prader-Willi syndrome (PWS), an imprinted neurodevelopmental disorder characterized by metabolic, sleep, and neuropsychiatric features, is caused by the loss of paternal SNORD116 , containing only noncoding RNAs. The primary SNORD116 transcript is processed into small nucleolar RNAs (snoRNAs), which localize to nucleoli, and their spliced host gene 116HG , which is retained at its site of transcription. While f...

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Literature Corpus work: 9d3ea250-9153-5367-b358-f19e6395f5b4
DOI: 10.1101/305557

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