Article

TCR repertoire analysis quantifies effect of irradiation to homeostasis of iNKT cell development in the thymus of mice

2025-05-15

Abstract excerpt

Thymic T cell development shows homeostasis in which T cell production recovers after temporal impairment by various stressors. Invariant natural killer T (iNKT) cells in the thymus contribute to recovery of thymic development after irradiation owing to their greater tolerance to irradiation compared to conventional thymocytes. However, whether and how iNKT cell development recovers from irradiation remains unknow...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d40f9e54-d8dd-55e1-9059-aaad0a6b7cf0
DOI: 10.1101/2025.05.12.653114

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TCR repertoire analysis quantifies effect of irradiation to homeostasis of iNKT cell development in the thymus of miceDOI 10.1101/2025.05.12.653114Read

Evaluation of TCR repertoire diversity in patients after hematopoietic stem cell transplantation.Semantic proximity Read

Impact of Aging on the Phenotype of Invariant Natural Killer T Cells in Mouse Thymus.Semantic proximity Read

Modelling the Dynamics of T-Cell Development in the ThymusSemantic proximity Read

Developmental dynamics of post-selection thymic DN iNKT.Semantic proximity Read

Process for immune defect and chromosomal translocation during early thymocyte development lacking ATMSemantic proximity Read

Sublethal Total Body Irradiation Causes Long-Term Deficits in Thymus Function by Reducing Lymphoid ProgenitorsSemantic proximity Read

Programmed Clonal Expansion Associated with V(D)J Recombination Drives an ATM-Dependent Vulnerability Underlying Preferential Lymphocyte Depletion and Myeloid Bias Following DNA DamageSemantic proximity Read

Generation and repair of thymic epithelial cellsSemantic proximity Read

Insights into immune system development and function from mouse T-cell repertoires.Semantic proximity Read

Thymic Function and T-Cell Receptor Repertoire Diversity: Implications for Patient Response to Checkpoint Blockade ImmunotherapySemantic proximity Read

Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity.Semantic proximity Read

DNA damage and repair during lymphoid development: antigen receptor diversity, genomic integrity and lymphomagenesis.Semantic proximity Read