Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thymic Function and T-Cell Receptor Repertoire Diversity: Implications for Patient Response to Checkpoint Blockade Immunotherapy

24 Nov 2021

Abstract excerpt

The capacity of T cells to recognize and mount an immune response against tumor antigens depends on the large diversity of the T-cell receptor (TCR) repertoire generated in the thymus during the process of T-cell development. However, this process is dramatically impaired by immunological insults, such as that caused by cytoreductive cancer therapies and infections, and by the physiological decline of thymic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to CAR-T cell therapy research
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34899700
DOI: 10.3389/fimmu.2021.752042

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thymic Function and T-Cell Receptor Repertoire Diversity: Implications for Patient Response to Checkpoint Blockade ImmunotherapyPMID 34899700Read ↗

T-cell repertoire diversity: friend or foe for protective antitumor response?Semantic proximity Read ↗

Evaluation of the TCR Repertoire as a Predictive and Prognostic Biomarker in Cancer: Diversity or Clonality?Semantic proximity Read ↗

Human TCR repertoire in cancerSemantic proximity Read ↗

Dynamics of thymus function and T cell receptor repertoire breadth in health and diseaseSemantic proximity Read ↗

T-Cell Receptor Repertoire Sequencing in the Era of Cancer ImmunotherapySemantic proximity Read ↗

Low-avidity T cells drive endogenous tumor immunity in mice and humansSemantic proximity Read ↗

Low avidity T cells drive endogenous tumor immunity in mice and humansSemantic proximity Read ↗

T cell receptor repertoire characteristics both before and following immunotherapy correlate with clinical response in mesotheliomaSemantic proximity Read ↗

Evaluation of TCR repertoire diversity in patients after hematopoietic stem cell transplantation.Semantic proximity Read ↗

The Diagnostic, Prognostic, and Therapeutic Potential of Adaptive Immune Receptor Repertoire Profiling in CancerSemantic proximity Read ↗

Characteristics and prognostic significance of profiling the peripheral blood T‐cell receptor repertoire in patients with advanced lung cancerSemantic proximity Read ↗

From thymus to tissues and tumors: A review of T-cell biologySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.