Article

Senescent cells in Giant Cell Arteritis have inflammatory phenotype participating in tissue injury via IL-6 dependent pathways

2023-05-19

Abstract excerpt

<h4>Objectives</h4> Age is the strongest risk factor of Giant Cell Arteritis (GCA), implying a possible pathogenetic role of cellular senescence. To address this question, we applied an established senescence specific multi-marker algorithm in tissue artery biopsies (TABs) of GCA patients. <h4>Methods</h4> Seventy five positive TABs from GCA patients and 22 negative from patients with Polymyalgia Rheumatica (PMR...

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Literature Corpus work: d407bf69-af90-5c52-8c78-5b1184af778c
DOI: 10.1101/2023.05.19.541093

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