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Senescent cells in giant cell arteritis display an inflammatory phenotype participating in tissue injury via IL-6-dependent pathways.

Annals of the rheumatic diseases - 15 Feb 2024

Veroutis Dimitris, Argyropoulou Ourania D, Goules Andreas V, Kambas Konstantinos, Palamidas Dimitris Anastasios, Evangelou Konstantinos, Havaki Sophia, Polyzou Aikaterini, Valakos Dimitrios, Xingi Evangelia, Karatza Elli, Boki Kyriaki A, Cavazza Alberto, Kittas Christos, Thanos Dimitris, Ricordi Caterina, Marvisi Chiara, Muratore Francesco, Galli Elena, Croci Stefania, Salvarani Carlo, Gorgoulis Vassilis G, Tzioufas Athanasios G

Abstract excerpt

OBJECTIVES: Age is the strongest risk factor of giant cell arteritis (GCA), implying a possible pathogenetic role of cellular senescence. To address this question, we applied an established senescence specific multimarker algorithm in temporal artery biopsies (TABs) of GCA patients. METHODS: 75(+) TABs from GCA patients, 22(-) TABs from polymyalgia rheumatica (PMR) patients and 10(-) TABs from non-GCA/non-PMR...

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Identifiers

PMID: 38050005
DOI: 10.1136/ard-2023-224467

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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