Article

A macrophage-smooth muscle cell axis influences vascular remodeling through activation of the EGFR pathway in giant cell arteritis

2024-11-06

Abstract excerpt

<h4>Background.</h4> The role of macrophages and vascular resident cells appears to be predominant in the pathophysiology of giant cell arteritis (GCA). We investigated the role of epithelial growth factor receptor (EGFR) signaling pathway, especially through its activation by heparin-binding epidermal growth factor (HB-EGF) and/or amphiregulin (AREG) in this setting. <h4>Materials and Methods.</h4> Serum sample...

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Literature Corpus work: c6ca6605-83a7-5502-96a2-e03efdddaa37
DOI: 10.1101/2024.10.31.621431

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