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Integrated analysis of the diagnostic value and mechanism of action of the senescence-associated secretory phenotype in thoracic aortic aneurysm relying on bulk RNA-Seq and scRNA-Seq

2025-11-06

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<title>Abstract</title> <p>Background Thoracic aortic aneurysm (TAA) eventually causes aortic intima rupture, and the senescence-associated secretory phenotype (SASP) has been found to promote TAA. Thus, identifying TAA early via SASP-related genes (SASP-RGs) is highly significant. Methods Differential analysis was performed on TAA datasets from GEO; SASP-RGs were expanded via weighted gene co-expression network...

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Literature Corpus work
5cdcec39-8864-55dd-a7b9-ebd2e15cc354
DOI
10.21203/rs.3.rs-7912284/v1
Open publication

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Integrated analysis of the diagnostic value and mechanism of action of the senescence-associated secretory phenotype in thoracic aortic aneurysm relying on bulk RNA-Seq and scRNA-SeqDOI 10.21203/rs.3.rs-7912284/v1
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