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Article

Cross-Trait Meta-Analysis Reveals a Genetic Link between Inflammation and Aging in Giant Cell Arteritis.

Aging and disease - 5 Aug 2025

Martínez-Gutiérrez Laura, Rodriguez-Martin Inmaculada, Borrego-Yaniz Gonzalo, Kerick Martin, Salvarani Carlo, Hernández-Rodríguez José, Cid María Cinta, González-Gay Miguel Ángel, Morgan Ann W, Martín Javier, Ortiz-Fernández Lourdes, Márquez Ana

Abstract excerpt

Giant cell arteritis (GCA) is a complex inflammatory disease affecting individuals over 50 suggesting a strong link with aging-related immune and vascular changes. However, the precise mechanisms underlying this age-related susceptibility remain poorly understood. Considering the relevance of aging in GCA, genetic factors influencing biological aging markers, such as telomere shortening and epigenetic age...

Topics

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Aging
ATXN2 gene
SERPING1 gene
Genetic Predisposition to Disease
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Giant Cell Arteritis

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 40901985
DOI: 10.14336/AD.2025.0609
PMCID: PMC13437121

Genes

GCA
ATXN2
PDE1B
PLG
PTPN22
SAR1B
SERPING1
SESN1
SMC4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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