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Article

Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts

4 Dec 2019

Abstract excerpt

Parkinson's disease (PD) and Multiple System Atrophy (MSA) are clinically distinctive diseases that feature a common neuropathological hallmark of aggregated α-synuclein. Little is known about how differences in α-synuclein aggregate structure affect disease phenotype. Here, we amplified α-synuclein aggregates from PD and MSA brain extracts and analyzed the conformational properties using fluorescent probes, NMR...

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PMID: 31797870
DOI: 10.1038/s41467-019-13564-w

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