Article

Comparative analysis of total alpha-synuclein (αSYN) immunoassays reveals that they do not capture the diversity of modified αSYN proteoforms

2022-03-14

Abstract excerpt

<h4>Background</h4> The development of therapeutics for Parkinson’s disease (PD) requires the establishment of biomarker assays to enable stratifying patients, monitoring disease progression and assessing target engagement. Attempts to develop diagnostic assays based on detecting levels of the α-synuclein (αSYN) protein, a central player in the pathogenesis of PD, have yielded inconsistent results. <h4>Objective<...

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Literature Corpus work: 00cc52c5-e8a4-5433-a5ea-676ca88286d9
DOI: 10.1101/2022.03.11.483980

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