Article

Super-enhancer switching drives a burst in germline gene expression at the mitosis-to-meiosis transition

2020-03-11

Abstract excerpt

The testis has the most diverse and complex transcriptome of all organs due to bursts in expression of thousands of germline-specific genes. Much of this unique gene expression takes place when mitotic germ cells differentiate and enter into meiotic prophase. Here, we demonstrate that the genome-wide reorganization of super-enhancers (SEs) drives bursts of germline genes after the mitosis-to-meiosis transition. At...

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Literature Corpus work: 711eb8c8-52a1-56de-b45e-c491bfdb20da
DOI: 10.1101/2020.03.11.987180

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