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Article

Super-enhancer switching drives a burst in gene expression at the mitosis-to-meiosis transition.

Nature structural & molecular biology - 1 Oct 2020

Maezawa So, Sakashita Akihiko, Yukawa Masashi, Chen Xiaoting, Takahashi Kazuki, Alavattam Kris G, Nakata Ippo, Weirauch Matthew T, Barski Artem, Namekawa Satoshi H

Abstract excerpt

Owing to bursts in the expression of thousands of germline-specific genes, the testis has the most diverse and complex transcriptome of all organs. By analyzing the male germline of mice, we demonstrate that the genome-wide reorganization of super-enhancers (SEs) drives bursts in germline gene expression after the mitosis-to-meiosis transition. SE reorganization is regulated by two molecular events: the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32895557
DOI: 10.1038/s41594-020-0488-3
PMCID: PMC8690596

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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