Article
Genome-wide DNA methylation changes in human spermatogenesis
2023-11-01
Abstract excerpt
<h4>Summary</h4> Sperm production and function require the correct establishment of DNA methylation patterns in the germline. Here, we examined the genome-wide DNA methylation changes during human spermatogenesis and its alterations in disturbed spermatogenesis. We found that spermatogenesis is associated with remodeling of the methylome, comprising a global-decline in DNA methylation in primary spermatocytes fol...
Topics
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- Epigenetics and DNA Methylation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Genetic Syndromes and Imprinting
- Molecular Biology Techniques and Applications
- Prenatal Screening and Diagnostics
- Renal and related cancers
- Reproductive Biology and Fertility
- Sperm and Testicular Function
Identifiers and source
- Literature Corpus work
- f8959618-c260-5a7b-a626-8a4846bf5b17
- DOI
- 10.1101/2023.10.27.564382
