Article

CTCF-mediated 3D chromatin predetermines the gene expression program in the male germline

2023-12-02

Abstract excerpt

Spermatogenesis is a unidirectional differentiation process that generates haploid sperm, but how the gene expression program that directs this process is established is largely unknown. Here we determine the high-resolution 3D chromatin architecture of male germ cells during spermatogenesis and show that CTCF-mediated 3D chromatin predetermines the gene expression program required for spermatogenesis. In undiffer...

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Literature Corpus work: 30c499fb-291d-57b6-b08b-a0833fa9ef2d
DOI: 10.1101/2023.11.30.569508

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