Article

A redox-shifted fibroblast subpopulation emerges in the fibrotic lung

2023-09-24

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is an aggressive and thus far incurable disease, characterized by aberrant fibroblast-mediated extracellular matrix deposition. Our understanding of the disease etiology is incomplete; however, there is consensus that a reduction-oxidation (redox) imbalance plays a role. In this study we use the autofluorescent properties of two redox molecules, NAD(P)H and FAD, to quantify chan...

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Literature Corpus work: d3e9f5e6-4daf-5f79-9e98-31ccf88999d9
DOI: 10.1101/2023.09.23.559128

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