Article

Loss of Fas-signaling in pro-fibrotic fibroblasts impairs homeostatic fibrosis resolution and promotes persistent pulmonary fibrosis

2020-08-19

Abstract excerpt

<h4>ABSTRACT</h4> Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible fibrotic disease of the distal lung alveoli that culminates in respiratory failure and reduced lifespan. Unlike normal lung repair in response to injury, IPF is associated with the accumulation and persistence of fibroblasts and myofibroblasts and continued production of collagen and other extracellular matrix (ECM) components. P...

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Literature Corpus work: cf9e35cb-8043-557a-8200-cfa0f59a5dd0
DOI: 10.1101/2020.08.18.255869

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