Article

Activation of the impaired NAMPT/SIRT7/SOD2 axis restores alveolar progenitor cell homeostasis in idiopathic pulmonary fibrosis and reverses pulmonary fibrosis in mice

2025-07-03

Abstract excerpt

<h4>Summary</h4> Alveolar type II (AT2) progenitor cell exhaustion and impaired regenerative capacity are key pathogenic hallmarks in idiopathic pulmonary fibrosis (IPF). Nicotinamide adenine dinucleotide (NAD + ) functions as a central regulator of cellular energy metabolism. We have reported that downregulation of NAD + -dependent sirtuin signaling contributes to the impaired progenitor function of IPF AT2s....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e410ae97-2f92-5379-9619-2440671e196b
DOI: 10.1101/2025.06.30.662456

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Activation of the impaired NAMPT/SIRT7/SOD2 axis restores alveolar progenitor cell homeostasis in idiopathic pulmonary fibrosis and reverses pulmonary fibrosis in miceDOI 10.1101/2025.06.30.662456Read

Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in CancerSemantic proximity Read

Zinc Metabolic Defect of Aging Alveolar Progenitors in Progressive Pulmonary FibrosisSemantic proximity Read

Roles of sirtuin family members in chronic obstructive pulmonary diseaseSemantic proximity Read

Nicotinamide N-methyltransferase mediates lipofibroblast–myofibroblast transition and apoptosis resistanceSemantic proximity Read

Loss of ANT1 Increases Fibrosis and Epithelial Cell Senescence in Idiopathic Pulmonary FibrosisSemantic proximity Read

Single-Cell Transcriptomics Identifies Dysregulated Metabolic Programs of Aging Alveolar Progenitor Cells in Lung FibrosisSemantic proximity Read

<i>Let-7</i> restrains an oncogenic circuit in AT2 cells to prevent fibrogenic cell intermediates in pulmonary fibrosisSemantic proximity Read

Rewired NAD <sup>+</sup> metabolism promotes NF-κB-mediated oxidative stress and disrupts lipid homeostasis in liver fibrosis progressionSemantic proximity Read

Identification a novel subset of alveolar type 2 cells expanding following pneumonectomy and enriched in PD-L1Semantic proximity Read

Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors.Semantic proximity Read

NAD <sup>+</sup> activates renal metabolism and protects from chronic kidney disease in a model of Alport syndromeSemantic proximity Read

NAMPT as a Dedifferentiation-Inducer Gene: NAD+ as Core Axis for Glioma Cancer Stem-Like Cells MaintenanceSemantic proximity Read