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A Redox-Shifted Fibroblast Subpopulation Emerges in the Fibrotic Lung

3 Jul 2024

Abstract excerpt

Abstract Idiopathic pulmonary fibrosis (IPF) is an aggressive and, thus far, incurable disease characterized by aberrant fibroblast-mediated extracellular matrix deposition. Our understanding of the disease etiology is incomplete; however, there is consensus that a reduction-oxidation (redox) imbalance plays a role. In this study, we use the autofluorescent properties of two redox molecules, NAD(P)H and FAD, to...

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Identifiers

PMID: 38959411
DOI: 10.1165/rcmb.2023-0346oc

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