Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Constitutive stable DNA replication in Escherichia coli cells lacking type 1A topoisomerase activity.

DNA repair - 1 Nov 2015

Martel Makisha, Balleydier Aurélien, Sauriol Alexandre, Drolet Marc

Abstract excerpt

Type 1A topoisomerases (topos) are ubiquitous enzymes involved in supercoiling regulation and in the maintenance of genome stability. Escherichia coli possesses two type 1A enzymes, topo I (topA) and topo III (topB). Cells lacking both enzymes form very long filaments and have severe chromosome segregation and growth defects. We previously found that RNase HI overproduction or a dnaT::aph mutation could...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Segregation
Share to DNA, Bacterial
Share to DNA Replication

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Topoisomerases, Type I

Share to Escherichia coli

Share to Escherichia coli Proteins

Share to Genomic Instability

Share to Ribonuclease H

Source

Identifiers

PMID: 26444226
DOI: 10.1016/j.dnarep.2015.08.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Constitutive stable DNA replication in Escherichia coli cells lacking type 1A topoisomerase activity.PMID 26444226Read ↗

Mutations reducing replication from R-loops suppress the defects of growth, chromosome segregation and DNA supercoiling in cells lacking topoisomerase I and RNase HI activity.Semantic proximity Read ↗

Countermeasures to survive excessive chromosome replication in Escherichia coli.Semantic proximity Read ↗

Bacterial type 1A topoisomerases maintain the stability of the genome by preventing and dealing with R-loop-and nucleotide excision repair-dependent topological stressSemantic proximity Read ↗

Type I topoisomerase activity is required for proper chromosomal segregation in Escherichia coli.Semantic proximity Read ↗

Hyperinitiation of DNA replication in Escherichia coli leads to replication fork collapse and inviability.Semantic proximity Read ↗

Chromosome demise in the wake of ligase-deficient replication.Semantic proximity Read ↗

Escherichia coli PriA protein is essential for inducible and constitutive stable DNA replication.Semantic proximity Read ↗

DNA polymerase I and the bypassing of RecA dependence of constitutive stable DNA replication in Escherichia coli rnhA mutants.Semantic proximity Read ↗

Replication of the Escherichia coli chromosome in RNase HI-deficient cells: multiple initiation regions and fork dynamics.Semantic proximity Read ↗

Controlled initiation of chromosomal replication in Escherichia coli requires functional Hda protein.Semantic proximity Read ↗

RecA, Tus protein and constitutive stable DNA replication in Escherichia coli rnhA mutants.Semantic proximity Read ↗

Lethal effects of a hyperactive dGTP triphosphohydrolase in E. coli.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.