Article
A genetic model for development, physiology and behavior of catecholamine-deficient zebrafish larvae.
Communications biology - 5 Aug 2026
Paredes-Zúñiga Susana, Veit Rebecca, Østevold Kristine, Arrey Gerard, Wehrle Johanna, Frank Dennis, Oswald Johannes, Veit Florian, Schredelseker Theresa, Glauben Sandra, Holzschuh Jochen, Driever Wolfgang
Abstract excerpt
Dopamine and noradrenaline have conserved roles in control of physiology and behaviors of vertebrates. However, vertebrate genetic models completely devoid of catecholamines are not available. We generated genetically catecholamine-free zebrafish larvae by combining mutations in all three genes involved in L-DOPA biosynthesis: the tyrosine hydroxylase genes th and th2, and tyrosinase tyr. Here we show that...
Topics
- Animals
- Zebrafish
- Catecholamines
- Larva
- Tyrosine 3-Monooxygenase
- Zebrafish Proteins
- Models, Genetic
- Behavior, Animal
- Levodopa
- Mutation
- Animals, Genetically Modified