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Article

Phenotypic Profiling of MPTP-Induced Parkinsonian-like Behavioral Phenotypes in Zebrafish Larvae Based on Behavioral Experiment.

Journal of visualized experiments : JoVE - 15 May 2026

Miao Zhuang, Bi Jiying, Zhang Jie, Tian Min, Yan Zhuoran, Duan Ruonan, Wang Ning, Li Xiang

Abstract excerpt

This article introduces a unique, multiparametric behavioral phenotyping protocol for MPTP-induced Parkinson's disease (PD) in larval zebrafish. Chemical induction of PD-like pathology in zebrafish provides a high-throughput, genetically tractable system, yet most studies have focused narrowly on basic locomotor assays or simple light-dark transitions. Such limited approaches fail to capture the broader spectrum...

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Behavior, Animal
Disease Models, Animal
Larva
Parkinsonian Disorders
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 42224176
DOI: 10.3791/70041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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