Article

Deconstructing intratumoral heterogeneity through multiomic and multiscale analysis of serial sections

2023-06-22

Abstract excerpt

Tumors may contain billions of cells including distinct malignant clones and nonmalignant cell types. Clarifying the evolutionary histories, prevalence, and defining molecular features of these cells is essential for improving clinical outcomes, since intratumoral heterogeneity provides fuel for acquired resistance to targeted therapies. Here we present a statistically motivated strategy for deconstructing intratu...

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Literature Corpus work: d3b227d5-3de5-565e-8983-25dbbfc7aeee
DOI: 10.1101/2023.06.21.545365

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