Article

Surveying Brain Tumor Heterogeneity by Single-Cell RNA Sequencing of Multi-sector Biopsies

2020-01-19

Abstract excerpt

<h4>ABSTRACT</h4> Brain tumors are among the most challenging human tumors for which the mechanisms driving progression and heterogeneity remain poorly understood. We combined single-cell RNA-seq with multisector biopsies to sample and analyze single-cell expression profiles of gliomas from 13 Chinese patients. After classifying individual cells, we generated a spatial and temporal landscape of glioma that reveal...

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Literature Corpus work: db3859b8-2ccf-585e-aaba-109b0d53e3fb
DOI: 10.1101/2020.01.19.911701

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