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Article

scONE-seq: A single-cell multi-omics method enables simultaneous dissection of phenotype and genotype heterogeneity from frozen tumors.

Science advances - 4 Jan 2023

Yu Lei, Wang Xinlei, Mu Quanhua, Tam Sindy Sing Ting, Loi Danson Shek Chun, Chan Aden K Y, Poon Wai Sang, Ng Ho-Keung, Chan Danny T M, Wang Jiguang, Wu Angela Ruohao

Abstract excerpt

Single-cell multi-omics can provide a unique perspective on tumor cellular heterogeneity. Most previous single-cell whole-genome RNA sequencing (scWGS-RNA-seq) methods demonstrate utility with intact cells from fresh samples. Among them, many are not applicable to frozen samples that cannot produce intact single-cell suspensions. We have developed scONE-seq, a versatile scWGS-RNA-seq method that amplifies...

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Identifiers

PMID: 36598983
DOI: 10.1126/sciadv.abp8901
PMCID: PMC9812385

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