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Article

ADAR1 deletion induces NF<i>κ</i>B and interferon signaling dependent liver inflammation and fibrosis

30 Jun 2016

Abstract excerpt

Adenosine deaminase acting on RNA (ADAR) 1 binds and edits double-stranded (ds) RNA secondary structures found mainly within untranslated regions of many transcripts. In the current research, our aim was to study the role of ADAR1 in liver homeostasis. As previous studies show a conserved immunoregulatory function for ADAR1 in mammalians, we focused on its role in preventing chronic hepatic inflammation and the...

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Identifiers

PMID: 27362366
DOI: 10.1080/15476286.2016.1203501

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