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Article

Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2015

Baum Rebecca, Sharma Shruti, Carpenter Susan, Li Quan-Zhen, Busto Patricia, Fitzgerald Katherine A, Marshak-Rothstein Ann, Gravallese Ellen M

Abstract excerpt

Innate immune pattern recognition receptors sense nucleic acids from microbes and orchestrate cytokine production to resolve infection. Inappropriate recognition of host nucleic acids also results in autoimmune disease. In this study, we use a model of inflammation resulting from accrual of self DNA (DNase II(-/-) type I IFN receptor [Ifnar](-/-)) to understand the role of pattern recognition receptor-sensing...

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Share to Antibody Formation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25548216
DOI: 10.4049/jimmunol.1402573
PMCID: PMC4299698

Genes

AIM2
TLR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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