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Article

RIG-I-like receptors and autoimmune diseases.

Current opinion in immunology - 1 Dec 2015

Kato Hiroki, Fujita Takashi

Abstract excerpt

Type I interferon (IFN) plays an essential role in antiviral innate immune responses and also in adaptive immune responses. Defects in the production of IFN markedly increase susceptibility to viral invasion and attenuate the acquired immunity. Recently an increased expression of type I IFN, also termed IFN signature, has been reported in patients with autoimmune diseases such as systemic lupus erythematosus...

Topics

Animals
Autoimmune Diseases
DEAD Box Protein 58
DEAD-box RNA Helicases
Humans
Interferon Type I
Interferon-Induced Helicase, IFIH1
Mice
Mice, Mutant Strains
Mutation
RNA, Viral
Receptors, Immunologic

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Identifiers

PMID: 26530735
DOI: 10.1016/j.coi.2015.10.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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