Article
RIG-I-like receptors and autoimmune diseases.
Current opinion in immunology - 1 Dec 2015
Kato Hiroki, Fujita Takashi
Abstract excerpt
Type I interferon (IFN) plays an essential role in antiviral innate immune responses and also in adaptive immune responses. Defects in the production of IFN markedly increase susceptibility to viral invasion and attenuate the acquired immunity. Recently an increased expression of type I IFN, also termed IFN signature, has been reported in patients with autoimmune diseases such as systemic lupus erythematosus...
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