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Article

An unexpected role for RNA-sensing toll-like receptors in a murine model of DNA accrual.

Clinical and experimental rheumatology - 1 Jan 2000

Pawaria Sudesh, Moody Krishna L, Busto Patricia, Nündel Kerstin, Baum Rebecca, Sharma Shruti, Gravallese Ellen M, Fitzgerald Katherine A, Marshak-Rothstein Ann

Abstract excerpt

OBJECTIVES: The goal of this study was to determine whether endosomal Toll-like receptors (TLRs) contribute to the clinical manifestation of systemic autoimmunity exhibited by mice that lack the lysosomal nuclease DNaseII. METHODS: DNaseII/IFNaR double deficient mice were intercrossed with Unc93b13d/3d mice to generate DNaseII-/-mice with non-functional endosomal TLRs. The resulting triple deficient mice were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26457825
PMCID: PMC4731237

Genes

TLR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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