Article

RNF115 deficiency upregulates autophagy and inhibits hepatocellular carcinoma growth

2023-01-18

Abstract excerpt

<title>Abstract</title><p>E3 ubiquitin ligase Ring finger protein 115 (RNF115), also known as Breast cancer-associated gene 2 (BCA2) has been linked with the proliferation, migration, and invasion of breast cancer. Our study demonstrated that RNF115 is a negative regulator of autophagy in hepatoma cells. Inactivation of<italic>RNF115</italic>can promote autophagosome formation, the fusion of autophagosomes with ly...

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Literature Corpus work: 85f39d02-3fe5-5928-b9cb-8102d07baf98
DOI: 10.21203/rs.3.rs-2405532/v1

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