Article

The TP53-activated E3 ligase RNF144B is a tumour suppressor that prevents genomic instability

2023-09-06

Abstract excerpt

<title>Abstract</title> <p> The tumor suppressor protein TP53 regulates a vast transcriptional program that serves protective mechanisms against cancer development. However, the complexity of this program makes it difficult to unravel the role of each of its targets in TP53-mediated tumour suppression. Knockdown of RNF144B, a E3-ubiquitin ligase transcriptionally regulated by TP53, enhanced the rate of tumour...

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Literature Corpus work: 3bc95d84-b388-5a87-936f-fca3823733fc
DOI: 10.21203/rs.3.rs-3182249/v2

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