Article

The Role of UBR2 in Triple-Negative Breast Cancer and Its Implications for Immune Checkpoint Blockade Therapy

2025-01-20

Abstract excerpt

<title>Abstract</title> <p>Objective UBR2 (also referred to as n-recognin 2, the E3 component of ubiquitin protein ligase) targets proteins with unstable N-terminal residues for polyubiquitination and proteasome-mediated degradation. It was initially identified as a crucial oncogene during embryonic development. Nevertheless, the function of UBR2 in triple-negative breast cancer (TNBC) and its non-ubiquitination...

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Literature Corpus work: 8dabb5d6-e208-51cc-9f86-ec306811eb9b
DOI: 10.21203/rs.3.rs-5746807/v1

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