Article

Decoding Plasticity Regulators and Transition Trajectories in Glioblastoma with Single-cell Multiomics

2025-05-13

Abstract excerpt

Glioblastoma (GB) is one of the most lethal human cancers, marked by profound intratumoral heterogeneity and near-universal treatment resistance. Cellular plasticity, the capacity of cancer cells to transition between phenotypic states, drives GB progression and resistance. However, the regulatory logic that permits or restricts specific state transitions remains poorly understood. Here, we integrated single-nucle...

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Literature Corpus work: f6afc855-60bc-50ff-a3d4-c3c48fec9280
DOI: 10.1101/2025.05.13.653733

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