Article

Three-dimensional regulatory hubs support oncogenic programs in glioblastoma

2024-12-20

Abstract excerpt

<h4>SUMMARY</h4> Dysregulation of enhancer-promoter communication in the context of the three-dimensional (3D) nucleus is increasingly recognized as a potential driver of oncogenic programs. Here, we profiled the 3D enhancer-promoter networks of primary patient-derived glioblastoma stem cells (GSCs) in comparison with neuronal stem cells (NSCs) to identify potential central nodes and vulnerabilities in the regula...

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Literature Corpus work: 678a1e25-411e-53a3-bfb8-0333bcfed1a9
DOI: 10.1101/2024.12.20.629544

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