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Article

Dr.Nod: computational framework for discovery of regulatory non-coding drivers in tissue-matched distal regulatory elements.

Nucleic acids research - 28 Feb 2023

Tomkova Marketa, Tomek Jakub, Chow Julie, McPherson John D, Segal David J, Hormozdiari Fereydoun

Abstract excerpt

The discovery of cancer driver mutations is a fundamental goal in cancer research. While many cancer driver mutations have been discovered in the protein-coding genome, research into potential cancer drivers in the non-coding regions showed limited success so far. Here, we present a novel comprehensive framework Dr.Nod for detection of non-coding cis-regulatory candidate driver mutations that are associated with...

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PMID: 36625266
DOI: 10.1093/nar/gkac1251
PMCID: PMC9976879

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